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Zopiclone is extensively and quickly metabolised because of the liver. A large number of metabolites are isolated and characterised, Along with the two key ones remaining the N-oxide, made by oxidation of the piperazine nitrogen plus the N-desmethyl made by oxidative demethylation of the N-methyl piperazine. Only the N-oxide analogue has weak pharmacological exercise.

• preparat zawiera laktozę; osoby z nietolerancją galaktozy, niedoborem laktazy lub zespołem złego wchłaniania glukozy–galaktozy, nie powinny stosować tego preparatu.

Stosowanie leków uspokajających i nasennych o działaniu podobnym do benzodiazepin może prowadzić do rozwoju uzależnienia. Ryzyko wystąpienia uzależnienia zwiększa się wraz z wielkością stosowanej dawki oraz czasem trwania leczenia; jest również większe u osób z uzależnieniem od alkoholu, używek lub leków w wywiadzie oraz u chorych z zaburzeniami osobowości lub z zaburzeniami psychicznymi. Chorzy z tej grupy powinni pozostawać pod szczególną obserwacją lekarską.

inneholde andre virkestoff enn det som er oppgitt på pakningen. Disse kan være farlige eller skadelig i kombinasjon med andre legemidler du bruker

Autoradiographic scientific studies within the rat confirmed immediate distribution to the blood and peak tissue amounts at 0.5 hours in the liver, small intestines, belly, kidneys as well as the adrenals. Soon after twenty four hours the full residual radioactivity in the body from the rat was eight%.

EMA ble opprettet i 1995 for å sikre greatest mulig utnyttelse av Europas vitenskapelige ressurser for evaluering av, tilsyn med og overvåkning av legemidler.

Scientific studies with mice taken care of with zopiclone at dietary doses as much as one hundred mg/kg/working day confirmed no proof of drug-related carcinogenicity.

Akutt og alvorlig allergisk reaksjon med symptomer som feber, utslett, opphovning, pustebesvær og blodtrykksfall. Anafylaktisk sjokk er livstruende om gentleman ikke setter i gang med legemiddelbehandling i variety av antihistaminer og adrenalin.

If zopiclone is prescribed to a lady of childbearing prospective, she really should be warned to Speak to her doctor pertaining to discontinuation from the product or service if she intends to become or suspects she's Expecting.

Nedsatt konsentrasjon av zopiklon. Basert på info fra andre kraftige induktorer av CYP3A4 må person regne med at konsentrasjonen av zopiklon kan synke med i størrelsesorden eighty %.

In Australia, any unused drugs or waste product should be disposed of by taking to your local pharmacy.

Symptomatic and supportive remedy in an enough medical atmosphere is recommended, interest need to be paid out to respiratory and cardiovascular capabilities. Activated charcoal may possibly decrease here absorption of your medication if given within just one or two several hours soon after ingestion. In individuals who're not absolutely mindful or have impaired gag reflex, thought should be provided to administering activated charcoal through a nasogastric tube, once the airway is secured.

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